Physical-chemical understanding of membrane partitioning and permeation at an atomic resolution: towards in silico pharmacology
T Ossman - 2016 - theses.hal.science
… investigated interactions of various drugs with membranes, as … In section IV.1, we have
focused on drugs (eg, antiviral and … and charged lipids also induces membrane curvature. It also …
focused on drugs (eg, antiviral and … and charged lipids also induces membrane curvature. It also …
Pharmacology of novel approaches designed to target picornaviral infections
O Hasan - 2021 - repository.essex.ac.uk
… , and some extracts have proven antiviral activity. The aim of … A previously observed
interaction between lipid droplets (LDs… Some microalgae extracts also showed antiviral effects. …
interaction between lipid droplets (LDs… Some microalgae extracts also showed antiviral effects. …
Design, characterization, and application of antiviral agent screening platform
SH Park - 2020 - dr.ntu.edu.sg
… explore an influence of vesicle size on membrane partitioning that … the membrane
interaction profiles using multiple model … , the selectivity based on membrane curvature was …
interaction profiles using multiple model … , the selectivity based on membrane curvature was …
Structural and functional properties of viral membrane proteins
… plasma membrane to facilitate membrane curvature formation … interaction with viroporin is
the finding that the adamantane derivatives amantadine and rimantadine have inhibitory effect …
the finding that the adamantane derivatives amantadine and rimantadine have inhibitory effect …
Inhibitors of the M2 proton channel engage and disrupt transmembrane networks of hydrogen-bonded waters
JL Thomaston, NF Polizzi, A Konstantinidi… - Journal of the …, 2018 - ACS Publications
… of the antiviral drugs amantadine and rimantadine. Structural … high-resolution structures of
drugs that interact with and disrupt … bend slightly at Gly34 in the Inward closed rimantadine …
drugs that interact with and disrupt … bend slightly at Gly34 in the Inward closed rimantadine …
Amantadine and rimantadine inhibit hepatitis A virus replication through the induction of autophagy
R Sasaki-Tanaka, T Shibata, M Moriyama… - Journal of …, 2022 - Am Soc Microbiol
… some reports that amantadine, a broad-spectrum antiviral, … Previously, the interaction
of amantadine with lysosomes was … gene quantification obtained from a standard curve (41). …
of amantadine with lysosomes was … gene quantification obtained from a standard curve (41). …
Functional characterization of p7 viroporin from hepatitis C virus produced in a cell-free expression system
T Soranzo, S Cortès, F Gilde, M Kreir, C Picart… - Protein expression and …, 2016 - Elsevier
… of small molecule drugs such as amantadine, rimantadine, BIT225, … The single channel IV
curve was extracted from the all point … , amantadine is able to interact with the lipid bilayer and …
curve was extracted from the all point … , amantadine is able to interact with the lipid bilayer and …
[HTML][HTML] Potential antiviral action of alkaloids
… , such as rimantadine and amantadine for the inhibition and … curvature of the membranes,
thus preventing efficient virus–… of the cell membrane and then interaction with the membrane …
thus preventing efficient virus–… of the cell membrane and then interaction with the membrane …
Shedding light on the puzzle of drug-membrane interactions: Experimental techniques and molecular dynamics simulations
D Lopes, S Jakobtorweihen, C Nunes… - Progress in lipid …, 2017 - Elsevier
… of the effects of drugs on the biophysical properties of membranes … to have a curvature that
is more similar to biological cells and, … used to study drug-membrane interactions [9]. Similarly, …
is more similar to biological cells and, … used to study drug-membrane interactions [9]. Similarly, …
Binding and Proton Blockage by Amantadine Variants of the Influenza M2WT and M2S31N Explained
C Tzitzoglaki, A Wright, K Freudenberger… - Journal of medicinal …, 2017 - ACS Publications
… ) curves of amantadine and rimantadine in interaction with the … the antiviral potency of the
compounds against the naturally … tested in order to get a curve adequate for measurements. A …
compounds against the naturally … tested in order to get a curve adequate for measurements. A …